• Zánět a jeho ovlivnění SET
• Zvýšení využitelnosti antibiotik proteolytickými enzymy
• Angiologie, flebologie
• Diabetologie
• Gynekologie
• Chirurgie, traumatologie, ortopedie
• Imunologie
• Lymfologie
• ORL
• Pediatrie
• Revmatologie
• Sportovní medicína
• Stomatologie
• Urologie

Literatura
• Časopisy s Impact faktorem
• Ostatní literatura

• SPC Wobenzym
• SPC Phlogenzym

Interferon production in whole blood cultures from volunteers and rheumatoid arthritis patients after medication with oral enzymes

Lackovic V.,¹ Rovensky J.,¹ Horvathova M.,² Malis F.¹

¹Research Institute of Rheumatic Diseases, Piestany, Slovakia, ² Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.

Int. J. Immunotherapy 1997: XIII(3/4), pp. 159-165 

SO 112 (19-04-2) - (3-10-1)

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Summary

After oral administration of a combination of hydrolytic enzymes (Wobenzym®) the leukocyte system of healthy subjects and patients with rheumatoid arthritis (RA) responds to ConA and NDV in vitro through a different pattern of IFN-g and IFN-a production, respectively. In healthy subjects, after Wobenzym® medication the IFN-g as well as the IFN-a producing ability was increased. This cell system was not able to release a detectable level of IFN-g spontaneously and trypsin itself had no IFN-inducing ability. RA patients with deficient producing ability of leukocytes to ConA failed to be restored in IFN producing capacity by the enzyme preparation and were even more decreased in the production of IFN-g after enzyme treatment. Wobenzym® treatment of healthy volunteers reduced TGF-b1 concentration in their plasma. In contrast to these results, whole blood cells of these volunteers produced TGF-b1 spontaneously.