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Literatura
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Sebekova K.,1 Dammrich J.,2 Fierlbeck W.,3 Krivosikova Z.,1 Paczek L.,4 Heidland A.5 1 Clinic of Pharmacotherapy, Institute of Preventive and Clinical Medicine, Bratislava, Slovakia, 2 Institute of Pathology, University of Wuerzburg, Germany, 3 Clinic of Internal Medicine IV, University Erlangen-Nuernberg, Germany, 4 Transplantation Institute, Warsaw, Poland, 5 Department of Nephrology, University of Wuerzburg, Germany. Int. J. Immunotherapy 1997: XIII(3/4), pp 79-83 SO 112 (19-04-2) - (5-11-2) Summary The potential effect of systemic treatment with proteolytic enzymes on slowing down the progression of renal damage was investigated in two rat models of nonimmune mediated diseases. Subtotal nephrectomy in rats was used as a model of chronic renal failure, and Goldblatt hypertension served as a model of hypertension-induced renal injury. In both models administration of proteolytic enzymes resulted in the improvement of renal function (serum creatinine concentration, proteinuria), as well as slower development of tubulointerstitial fibrosis in comparison with the placebo treated animals. Moreover, in the model of hypertension-induced renal injury, the occurrence of malignant nephrosclerosis was also markedly reduced. These effects were independent of the rise in blood pressure. In conclusion, systemic treatment with proteolytic enzymes ameliorated the course of chronic renal failure, as well as that of the hypertension-induced renal injury in rats, and retarded the development of tubulointerstitial fibrosis. |
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