Systémová enzymoterapie pro odborníky

Potential of Targeting Cell Surface CD44 Proteins with Proteinases in Preventing Tumor Growth and Metastasis

Sy M.S.,¹ Liu D.,¹ Kogerman P.,² Culp L.A.²

¹Institute of Pathology, Case Western Reserve University, School of Medicine, Cleveland, USA, ²Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, USA.

Int J. Immunotherapy 1997: XIII(3/4), pp 105-109

SO 112 (19-04-2) - (1-08-2)

Summary

One of the adhesion molecules that has been implicated in playing a role in tumor growth and metastasis is the cell surface glycoprotein, CD44. CD44 is encoded by a single gene which is composed of at least 20 exons. The 70-90 KDa CD44 protein in leukocytes is the basic unit of CD44 protein. One of the ligands for CD44 is hyaluronic acid (HA), a polysaccharide present in tissues and in the circulation. Binding of HA to CD44 on tumor cells can enhance the spread of tumor cells by promoting tumor cell adhesion, motility, and activation of genes important in tumor invasion and metastasis. There is compelling evidence that in some tumor systems expression of CD44 proteins plays a critical role as a determinant of tumor cell invasion and metastasis. Preliminary experiments revealed that CD44 proteins on some tumor cells are sensitive to treatment with proteinases in vitro. Furthermore, tumor cells treated in vitro with proteinases are also less invasive in a Matrigel invasion assay. Collectively, this indirect evidence suggests that CD44 on tumor cells may be a target for proteolytic enzymes and may help to explain observations indicating that proteolytic enzymes have an antimetastatic potential in animal models.


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Zánět a jeho ovlivnění SET Zvýšení využitelnosti antibiotik proteolytickými enzymy Angiologie, flebologie Diabetologie Gynekologie Chirurgie, traumatologie, ortopedie Imunologie Lymfologie ORL Pediatrie Revmatologie Sportovní medicína Stomatologie Urologie Literatura Časopisy s Impact faktorem Ostatní literatura SPC Wobenzym SPC Phlogenzym	Potential of Targeting Cell Surface CD44 Proteins with Proteinases in Preventing Tumor Growth and Metastasis Sy M.S.,¹ Liu D.,¹ Kogerman P.,² Culp L.A.² ¹Institute of Pathology, Case Western Reserve University, School of Medicine, Cleveland, USA, ²Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, USA. Int J. Immunotherapy 1997: XIII(3/4), pp 105-109 SO 112 (19-04-2) - (1-08-2) Summary One of the adhesion molecules that has been implicated in playing a role in tumor growth and metastasis is the cell surface glycoprotein, CD44. CD44 is encoded by a single gene which is composed of at least 20 exons. The 70-90 KDa CD44 protein in leukocytes is the basic unit of CD44 protein. One of the ligands for CD44 is hyaluronic acid (HA), a polysaccharide present in tissues and in the circulation. Binding of HA to CD44 on tumor cells can enhance the spread of tumor cells by promoting tumor cell adhesion, motility, and activation of genes important in tumor invasion and metastasis. There is compelling evidence that in some tumor systems expression of CD44 proteins plays a critical role as a determinant of tumor cell invasion and metastasis. Preliminary experiments revealed that CD44 proteins on some tumor cells are sensitive to treatment with proteinases in vitro. Furthermore, tumor cells treated in vitro with proteinases are also less invasive in a Matrigel invasion assay. Collectively, this indirect evidence suggests that CD44 on tumor cells may be a target for proteolytic enzymes and may help to explain observations indicating that proteolytic enzymes have an antimetastatic potential in animal models.
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