Wald M. l, Olejár T. 2, Poucková P. 2, Zadinová M. 2
1 Department of Surgery, 2nd Medical Faculty
, Charles University, Prague, Czech Republic
Poster at ISH-EHA Combined Hematology Congress, July 4-8
The influence of proteolytic enzyme mixture was proved on spontaneous lymphoblastic leukemia development in our in vivo experiment in rat species SD/Ipcv. In the group treated by a mixture of trypsin, chymotrypsin and papain per rectum a significantly lower rate of blast cells in the peripheral blood during disease development was noticed. The average survival time in the experimental group was 150 +/- 45,62 days, in the control group 43,83 +/- 24,52 days since the appearance of the first blast cells. One half of the treated animals survived even until the end of our experiment (366 days) and was finally sacrificed. In the treated group two cases with no blast cells and in one occasion a very small number of blast cells were found at the end of experiment. The proteolytic enzyme mixture has also had a positive influence on the stable weight gain in animals in contrast to the weight loss of the control group in the terminal stage of the disease. The maximum count of all leukocytes in the time of exitus ranged between 9,9 x 109/l and 29,8 x 109/l in experimental animals and only in one animal the periphery was flooded by 37 % of blast cells. In the control group the numbers ranged between 21,6 x 109/l - 58,0 x 109/l and the presence of blast cells in the periphery was around 30 - 72 %.
Datum aktualizace stránky: 19. 1. 2016