Systemic enzyme treatment as a method of secondary prevention in
patients after myocardial infarction in the rehabilitation period
I.K. Sledzevskaya, M.V. Loboda, E.A. Kolesnik, L.N.Babiy, L.I.
Fisenko
Ukrainian Institute of Cardiology,"Ukrprofzdravniza", Kiyev,
Ukraine
Poster at II Mediterranean Congress of Physical Medicine and
Rehabilitation, May 20-23 1998, Valencia, Spain
Abstract
Despite its proved hypolipidemic and immunocorrective effects, Wobenzym
("Mucos Pharma" Germany) has not been used in patients with myocardial
infarction (MI) in period of rehabilitations.
The aim of this study was the
estimation of influence treatment with Wobenzym on lipids parameters,
antioxidant activity and immunological indices in patients after myocardial
infarction.
30 myocardial infarction patients in 3rd-4th week of the disease
were treated with Wobenzym. The patients also received beta-adrenoblockers,
nitrates, aspirin and inhibitors ACE.
Parallel experimental studies with two
rabbit groups with a hypercholesterolemia model were carried out. Cholesterol
content in plasma, blood pro- and antioxidant parameters and state of blood
monocytes were estimated.
Evident hypolipidemic effects (significant decrease
of cholesterol level) and immunocorrecting effects (significant decrease of
titer of antibodies to the infarcted myocardium and circulating immune
complexes) of Wobenzym were demonstrated in clinical and experimental
study.
Based on obtained results it can be recommended to use Wobenzym in
complex treatment of myocardial infarction patients to reduce risk factors of
reinfarction.