Systémová enzymoterapie pro odborníky

Polyenzyme Preparation WOBE-MUGOS^®Inhibits Growth of Solid Tumors and Development of Experimental Metastases in Mice

M. Wald¹, E. Závadová², P. Poucková³ , M. Zadinová³, M. Boubelík⁴

¹ Department of Surgery, Faculty Hospital Motol, Prague, Czech Republic; ² Dep. of Applied and Experimental Oncology, Institute for Tumor Biology Cancer Treatment, Vienna, Austria; ³ Institute of Biophysics, Prague, Czech Republic; ⁴ Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic

Life Sciences (PHARMACOLOGY LETTERS), Vol. 62, No. 3, pp. PL 43-48, 1998

Abstract

Long-term rectal administration of enzyme mixture containing papain, trypsin and chymotrypsin in the same ratio as the preparation Wobe-Mugos E (Mucos Pharma, Germany) was evaluated for its antitumor effects in C₅₇Bl₆inbred mice inoculated with B1₆ melanoma cells. 30% of animals in the test group (3 pcs) have been cured of cancer. In the rest of animals (70%) the survival time was prolonged by 58.3% compared to the control group (from average survival time of 24 days in control group to 38 days in the test group). Based on histological and immunohistochemical evaluation a faster process of metastasizing was found in control group than in the group treated with the polyenzyme preparation. In the case of melanoma Bl₆ an antimetastatic effect of the preparation was thus proved.


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