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The influence of trypsin, chymotrypsin and papain on the growth of human pancreatic adenocarcinoma transplanted to nu/nu mice

Wald M. (1); Poucková P. (2); Hloušková D. (2); Altnerová M. (2); Olejár T. (2)

1 Dep. of Surgery, 2^nd Medical Faculty, Charles University, Prague, Czech Republic
2 Institute of Biophysics, 1^st Medical Faculty, Charles University, Prague, Czech Republic

The European Journal of Cancer 1999; 35(4): No. 543, 148.

Purpose: The aim of the study as presented was to investigate the influence of protease mixture in a model of transplanted human pancreatic carcinoma based on our previous results in mice with syngenic tumor models.

Material and methods: After the 2 weeks of posttransplant latency, total of 18 nu/nu mice (CD-1 prone) bearing subcutaneously the human adenocarcinoma were at random divided into two equal groups. The 1^st one (enzyme group) was administered a trypsin, chymotrypsin and papain solution rectally. The 2^nd one (control group) was administered saline by the same way. The tumor growth in both groups was measured daily for following 30 days and the tumor mass was calculated from their extents.

Results: Along the presented study, protease mixture retards growth of human pancreatic adenocarcinoma in nu/nu mice. In the enzyme group, the tumor mass increased only up to 47.6% of the control volume in the 30^th day.

Conclusion: Although the proteases were expected to have mainly the antimetastatic effect in cancer progression, these results confirm growth inhibition of primary tumor by trypsin, chymotrypsin and papain solution.


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