Therapy of adnexitis - enhancement of the basic antibiotic therapy with
hydrolytic enzymes
F.-W. Dittmar1, E. R. Weissenbacher2
1 Department of Obstetrics and Gynecology, District
Hospital Starnberg, Teaching Hospital of the Ludwig-Maximilians-University
Munich, W-8130 Starnberg, FRG
2 Gynecologic Clinic, Clinic Center Großhadern, Ludwig-Maximilians-University
Munich, W-8000 Munich 70, FRG
International Journal of Experimental and Clinical Chemotherapy 1992: Vol. 5, No. 2, pp. 73-81
WE 12 (5-03-2) = WE 44 (5-04-2) něm.
Abstract
A total of 56 patients were recruited to a randomized double blind
study (28 to the enzymes and placebo group, respectively) and treated
for a period of 28 days in order to evaluate the effectiveness and tolerance
of an enzyme combination preparation as adjuvant of the initial 6-day
basic antibiotic treatment.
At the beginning of the investigation there were no differences between
the enzymes and the placebo group regarding the parameters characterizing
the process of recovery. At the end, however, such differences were
observed: body temperature in the enzymes group 37.0°C, in the placebo
group 37.2°C, p = 0.021; WBC in the enzymes group 8,800/m l, in the placebo group 10,100/m
l, p = 9.52 x 10-6; ESR after 1 h 14.8 mm/h and 19.5 mm/h
in the enzymes and placebo group, respectively, p = 0.003; score for
palpable tumors in the enzymes group 1.0 ("more resistant to touch than
normal on one side") and 3.0 in the placebo group ("bilateral resistance
to touch"), p = 1.28 x 10-7; score for tenderness on pressure
in the enzymes group 0 (nothing abnormal detected) and 2 in the placebo
group (uterus and adnexa), p = 4.42 x 10-7; score for vaginal
discharge in the enzymes group 0 ("white/normal") and 1 in the placebo
group ("slightly purulent and/or sanguineous"), p = 1.39 x 10-6.
The adnexitis score, defined as major criterion of effectiveness, gave
corresponding results: with comparable baseline values (enzymes = 12.2,
placebo = 11.3, p = 0.08) it was 2.6 in the enzymes group (subacute
adnexitis) and 7.7 in the placebo group (moderate adnexitis) at the
end of therapy (p = 7.45 x 10-7).
The results of this study suggest that the enzyme combination preparation
used is effective as adjuvant of basic antibiotic treatment in acute
adnexitis. There were no side effects in either group.
Key words: Therapy of adnexitis - adjuvant enzyme therapy - enzyme combination preparation vs. placebo - antiinflammatory effect
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